Protein name:
Aprataxin and PNK-like factor ;
Alternative:
Apurinic-apyrimidinic endonuclease APLF ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Interacts with LIG4, PARP1, XRCC1, XRCC4 and XRCC5.
Function:
Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.
Subcellular Location:
Nucleus
Cytoplasm
cytosol
Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers.
Protein Attributes:
50:
MSGGFELQPQ | DGGPRVALAP | GETVIGRGPL | LGLHRNPCYY | QSSEKSQLLP |
100:
LKTNIWCWLN | PGDHFSLLVD | KYIFCVLSTH | SEMEMECTLR | NSQMLDEDDI |
150:
LNEIPKSSSA | DLPDKTPSAP | RRERSTETAK | PQAAANNMSF | IGESRDLSKQ |
200:
QPNPSERKRI | LPAWMLTENS | SDQNLSVISG | GNNVTWESEK | ERVCKDKTQV |
250:
NITQPGKKRL | ISSGSSESTS | AKQDTGKKCK | NDDQEESIIS | SKEMPQSFSA |
300:
AMLHNTEIDN | TKTNPQRSKV | PVEALGKVSE | HKIITKGSSN | EDSTARSCSE |
350:
SYSSTQSKSF | CDKPQKSHPE | PSSNPPSPEC | VQAKATDSVP | NGSEENKVQR |
400:
TSCMYGANCY | RKNPVHFQHF | SHPGDSDYGG | VNITCQDEAD | DRPECPYGAS |
450:
CYRKNPQHKI | EYRHSTFPVR | SISDEDDNVG | QPNEYNLNDS | FIDDEEEEYE |
485:
PTDEDSDWEP | EKEDLEKEDM | EGLLKEAKKF | MKRKK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Bovine
ELISA Kit for Bovine Aprataxin and PNK-like factor
ELISA Kit for Bovine Aprataxin and PNK-like factor
ELISA Kit for Bovine Aprataxin and PNK-like factor
CLIA Kit for Bovine Aprataxin and PNK-like factor
CLIA Kit for Bovine Aprataxin and PNK-like factor
CLIA Kit for Bovine Aprataxin and PNK-like factor
Polyclonal Antibody for Bovine Aprataxin and PNK-like factor
Polyclonal Antibody for Bovine Aprataxin and PNK-like factor
Polyclonal Antibody for Bovine Aprataxin and PNK-like factor
Monoclonal Antibody for Bovine Aprataxin and PNK-like factor
Monoclonal Antibody for Bovine Aprataxin and PNK-like factor
Monoclonal Antibody for Bovine Aprataxin and PNK-like factor
Protein for Bovine Aprataxin and PNK-like factor
Protein for Bovine Aprataxin and PNK-like factor
Protein for Bovine Aprataxin and PNK-like factor
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Hypothalamus .